Product Basic Information
Product name    Tianeptine Sodium
CAS No.    30123-17-2  
EINECS    250-059-3
Molecular formula    C21H25ClN2NaO4S
Molecular weight    459.9414
Appearance    White powder
Solubility    DMSO: ≥20 mg/mL
Assay    ≥99% (HPLC)

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Product Details

Tianeptine has strong antidepressant and anxiolytic properties with a relative lack of sedative, anticholinergic and cardiovascular adverse effects, thus suggesting it is particularly suitable for use in elderly patients and in those following alcohol withdrawal; such patients can be more sensitive to the adverse effects of psychotropic drugs. Recent interesting results indicate anticonvulsant and analgesic activity of tianeptine and its possible interaction with adenosine A1 receptors.

Tianeptine is neuroprotective via multiple neurochemical and cellular mechanisms. In theory, tianeptine's neuroprotective action makes it a potential life-extension drug. When an organism is under stress, or perceives itself under stress, the hypothalamus secretes corticotropin-releasing hormone/factor (CRH/CRF). CRH/CRF in turn increases secretion of adrenocorticotrophic hormone (ACTH) from the anterior pituitary. ACTH in turn stimulates the release of glucocorticoids from the adrenal cortex. Persistent, uncontrolled physical and psychosocial stress causes excess cortisol secretion from the adrenal glands. Excess cortisol causes dendritic shrinkage in the hippocampus and a contrasting growth of dendrites in the lateral amygdala. These stress-induced changes tend to lower mood; they can cause clinical depression in the genetically vulnerable. Current evidence suggests that tianeptine acts to prevent and even reverse stress-induced neural damage, promoting both neuronal survival and synaptic plasticity. 

Certificate of analysia

Product	Tieneptine sodium powder
batch No.	202005001	Mfg. date	20200506
CAS No.	30123-17-2	Exp. date	20220505
Tests	Results	Specifications
Description	Off-white powder,very hygroscopic.	White to yellowish powder,very hygroscopic.
Solubility	Complies	Freetly soluble In water and methanol and dichloromethane
Identification	Complies	（1）By IR, To match with working standard
	Complies	（2）It gives reaction of sodium
Impurities A	Not detected	≤0.1%
Related compounds	＜0.1%	Any impurity ≤0.1%
	0.19%	Total impurities ≤0.4%
Residual  Solvents	Not detected	Acetidin≤ 0.5%
	0.04%	Dichloromethane≤ 0.06%
	0.01%	Methanol≤ 0.3%
	0.01%	Acetone ≤ 0.5%
	Not detected	Acetonitrile≤0.041%
	0.01%	Ethanol≤0.5%
	Not detected	N, N-dimethylformamide ≤0.088%
Water	2.35%	≤ 5.0%
Assay	99.35%	99.0%-101.0%（On anhydrous basis）
Conclusion： Conform to EP8.0

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